10-hydroxycamptothecin
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Product Property
Product Status : | New |
Sample Available : | yes |
Shipment Terms : | fob,cif,Negotiable |
Payment Mode : |
T/T,L/C,WesternUnion,Negotiable |
Description
Product Name: 10-hydroxycamptothecin Synonym: Spyrano[3, 4: 6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione Molecular Formula: C20H16N2O5 Formula Weight: 364.35 CAS No. 19685-09-7 ,7689-03-4 Botanical source: Camptotheca acuminata Decne Appearance: Light Yellow Crystal Powder Odor: Characteristic Solubility: Insoluble in water, its sodium salt is the water-soluble, its organic solution has blue fluorescence. Specification: 10-hydroxycamptothecin >98% Sieve analysis: 100% through 80 mesh Storage: Store in cool & dry place, Keep away from strong light and heat. Shelf life: 24Months when properly stored. Packing: Aluminum foil-bag and two plastic-bags inside Functions: 10-hydroxycamptothecin is the derivative of camptothecine that is a micro-alkaloid from camptotheca Acuminate (a tree native to mainland China). Is a kind of pharmaceutical intermediate, an alkaloid originally isolated from the Camptotheca acuminata, exerted inhibitory effects on DNA topoisomerase (Topo )[1]and has anticancer activity in vitro and in vivo. It can also induce differentiation of leukemia MELC[2]and HL-60[3]cells. The purpose of this study is to investigate the proliferation-inhibiting and differentiation-inducing actions of HCPT on human hepatoma Hep G2 cells. |